China in Africa

 

Thrombin loaded DNA origami fight cancer – animal experiments

The groups of Baoquan DING and colleagues at the National Center for Nanoscience and Technology (NCNST) in Beijing and of Hao YAN at Arizona State University have constructed DNA origami decorated with a DNA aptamer which specifically binds to nucleolin, a protein expressed on tumor-associated endothelial cells. The DNA origami contains thrombin which coagulates blood, thus inhibiting blood supply. When such vectors were i.v. injected to tumor-bearing mice, they were shown aggregate within 1 hour at the tumor, generated tumor tissue damage within 24 hours. Most of the nanorobots were cleared and degraded from the mouse body after 24 hours. By two days, there was evidence of advanced thrombosis, and after 3 days, thrombi in all tumor vessels were observed. in a melanoma mouse model, 3 out of 8 mice receiving the nanorobot therapy showed complete regression of the tumors. The median survival time more than doubled, extending from 20.5 to 45 days. The nanorobot proved to be safe and immunologically inert for use in normal mice and in mini pigs, showing no detectable changes in normal blood coagulation or cell morphology. There was no evidence of the nanorobots spreading into the brain (exclusion of stroke risks).

CAS news release, February 13, 2018

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BGI releases desktop HTP sequencer

The instrument, called Revolocity BGISEQ-500, will be delivered from February, 2017, and is one third less expensive than comparable instruments. It uses advanced combined probe anchor polymerization technology (cPAS) and DNA nanoparticles (DNB) sequencing technology. An icon touch operating system, compatible with automatic sample tracking management, provides optimized process guidance, and a card type sequencing chip integrated into the sequencing kit containing prefabricated high precision micro machining allows for 10 hours of automatic sample loading and sequencing in unattended mode. If equipped with an optional automated sample preparation system, the entire process including sample preparation is complete in 18 hrs.

China Bio news release, November 7, 2016

CAS Zhengzhou Fruit Research Institute reports genetic basis for peach aroma characteristics

The group around Lirong WANG has analaysed 12 gene regions associated with the characteristic taste and appearance of peaches, based on genome sequencing of 129 modern peach cultivars. For example, the acidity of a peach may be affected by the variation of plant hormone transporter gene expression, and the peache’s shape may be determined by the expression of apoptosis related proteins.

China Bio news release, November 11, 2016

220 varieties of traditional Chinese medicine (TCM) will be added to the Chinese Pharmaopoeia in 2020

As announced by the State Phamracopoeia Commission on its website, this will bring the total number of varieties to 6,400, of which about 220 varieties will be TCM. The safety standards of these varieties will be strongly improved (pesticide reidues, heavy metals, allergenics), and the identification of individual compounds will be further standardized.

China Bio news release, November 11, 2016

CAS Institute of Microbiology develops novel in-vitro pathogen detection system

The group of Chunbo LOU, together with the Peking iGEM team, developed a novel paired dCas9 reporter system. As a proof of concept, they successfully distinguished Mtb genome markers. The paired dCas9 reporter system is programmed by single guide RNAs complementary to the upstream and downstream segments of a target DNA sequence, respectively. When substrate DNA containing the two segment-sequences in proximity are detected and bound by a pair of dCas9, luminescence is generated from the catalytic activity of luciferase in its entirety. In this detection system, sequence information (including complementary sequence and spacer sequence) and output signal amplification are obtained simultaneously.

CAS news release, November 10, 2016

CAS led-team develops full-color 3D meta holography with single nanostructured layer

The research team, led by Xiangang Luo from the State Key Laboratory of Optical Technologies on Nano-fabrication and Micro-engineering, CAS, and Minghui Hong’s team from Department of Electrical and Computer Engineering, National University of Singapore, have demonstrated full-color 3D meta-holography imaging with extended viewing angles, realized by a single layer of nanostructured metallic surface. The usable data capacity and cross-talk limitations were improved and by using a single type of plasmonic pixel. This not only led to a remarkable image quality, with a signal-to-noise ratio (SNR) five times better than that of the previous meta-hologram designs, but to a full-color meta-holographic image in the 3D space, with pending applications in data storage, security, and authentication.

CAS news release, November 11, 2016

Group at USTC sets world distance record of 404 km for secure quantum communication

he group of Jianwei PAN at the University of Science and Technology of China (USTC) of CAS, have sent secure quantum protocol, known as measurement-device-independent quantum key distribution (MDIQKD), over a distance of 404 km. Compared with earlier experiments, they demonstrated a 500-fold increase in speed, reaching a key-distribution rate that would be sufficient to ensure encrypted voice transmission by telephone.

CAS news release, November 11, 2016

China will boost robot development

According to Zhongxue GAN, Dean of Ningbo Institute of Intelligent Manufacturing Industries, industrial robots in China will soon be developed into two-armed robots with online-sensing intelligence and some AI during the Made in China 2025″ program. “Robots in the factories can not only serve as the operator, but as well as workshop supervisor and leaders, even the president, which means that there are robots taking the worker’s job and robots taking the management position. The workshop achieving the coordinative work of human beings and robots can be called as the real intelligent workshop”.”

CAS news release, November 9, 2016

Merck KGaA invests 250 million € in its Nantong plant.

The investment is split in 170 million € for Nantong pharmaceutical base which will focus on the production of high quality Chinese medicine. In the inauguration ceremony, Merck also announced the establishment of life science center in Nantong with an investment of 80 million euros, specializing in the production of high purity inorganic salts and cell culture medium.

China Bio news release, November 7, 2016

US Amgen opens research center in Suzhou

The center will be built with Suzhou Medical Research Institute, under the Chinese Academy of Medical Sciences, and focus on tumor immunity-related projects.

CAS news release, November 7, 2016

Shenzhen’s Hong Rui Kang Biotechnology Co. launches personalized microbial skin care products

Based on individual diagnostic of the skin flora through a cotton swab-based skin analysis sent to the company and analyzed in a proprietary skin flora intervention database, the company offers skin care products which contain classical components such as skin softeners and moisturizing agents, but also GRAS microorganisms which are known to establish a healthy skin flora.

China Bio news release, November 4, 2016

China reports progress on biomass power generation

The three most important raw materials are straw (over 700 million t/year), municipal waste and livestock manure. China’s installed capacity for biomass energy power generation is second in the world: the current total installed capacity is 14,23 million kW, of which 9,5 million kW enter the grid. During 125″, agricultural mechanization, crop straw collection, bundling and transport efficiency has been greatly improved. In “135”, a focus will be on improving technologies and bringing it to the remoter parts of China.”

China Bio news release, November 11, 2016

Canada’s Global Drug Commercialization Center opens branch in Chengdu

Headquartered in Vancouver, The Centre for Drug Research and Development (CDRD) is Canada’s national drug development and commercialization engine. It works in partnership with academia, industry, government and foundations, to provide the specialized expertise and infrastructure to identify and de-risk promising discoveries generated by health-related research, and transform them into commercially viable investment opportunities for the private sector – and ultimately into innovative new therapies for patients.

China Bio news release, November 2, 2016