A group around Professor LAI Ren identified a peptide AH90 from frog skin which showed potential wound healing-promoting activity in a murine model with full thickness dermal wound. AH90 acts by activating NF-κB and c-Jun expression of cell signaling pathways resulting in upregulation of TGF-β, which can then activate downstream Smads by the TGF-β pathway.

Han LIU et al., International J. of Biochemistry and Cell Biology, http://dx.doi.org/10.1016/j.biocel.2014.01.010