A team around ZHANG Pumin from Beijing Proteome Research Center and several universities and military universities modified porcine albumin into human albumin and used CRISPR technology to express this gene in pigs. Approximately 300 embryos were implanted in 10 female pigs, of which five pigs gave birth to 16 cubs. The cubs showed no signs of any unusual health problem. By genotypic analysis, researchers found that the 16 cubs carried the desired gene sequence human blood serum protein. The modified allele was successfully passed on to the offspring. It is expected that these results will facilitate the use of pigs and other large domestic animals for the production of biomedical products.

China Bio news release, November 24, 2015