Prof. Chang CHEN has proposed a new concept based on studies with C. elegans and human fibroblast senescence cells. His results showed that compared with old worms or senescent cells, young worms or young cells could generate more reactive oxygen species (ROS) to activate Erk and Akt signal pathways in response to redox stress. Based on these results, he proposes a new concept RRC, which includes the ability to generate ROS/RNS to activate cellular signaling, the ability to activate the antioxidant system and to degrade the damaged proteins.

CAS news release, February 27, 2017