The toothpaste was developed at Fudan University, and Fe in its name relates to Fudan enzyme”. It was tested since 2004 in various demonstration projects and finally approved in 2016. “Fe biological toothpaste” should not be rinsed with water for 2-3 minutes, in order to give full play to the antimicrobial function of lysozyme. YHD is a Chinese subsidiary of US WalMart.”

China Bio news release, September 20, 2017