The group of JIN Gongsheng identified four potential Na+/H+ antiporters (Mrp1-2, NhaP and ChaA), and systematically described the physiological adaptation strategies of Corynebacterium glutamicum under saline and alkali stress conditions. They found that the Mrp1 protein of C. glutamicum has the most significant Na+/H+ ion transport activity, and this protein mainly plays a role under alkaline conditions. In vivo experiments further confirmed that the Mrp1 antiporter is mainly involved in the tolerance response of the strain under high NaCl and alkaline stress conditions, and the Mrp2 antiporter is mainly involved in the tolerance response of the strain under high KCl stress conditions. Loss at the same time will seriously affect the normal survival ability of the strain under high saline conditions.
CAS news release, April 26, 2018