The group of Lijun WU at the Center’s Institute of Technology, Biology and Agriculture constructed a three-dimensional (3D) cell-based novel genotoxicity detection system based on the the CD59 AL mutation detection system. First, a 3D cell mass was obtained by a low adhesion culture method. Relatively stable and uniform 3D cell cultures were used to examine the oncogenic effects of environmental contaminants, nanosilver and arsenic. Results differed from those obtained with 2D cell cultures and relate closer to other geontoxicity tests.
CAS news release, June 25, 2018