The nanodrop system achieves nanoliter volume addition of different reagent components through high-precision micro-volume control. It is compatible with 96 and 384-well plates and can be programmed according to the pre-filled mineral oil plate. The minimum volume that can be accurately filled with a low-cost probe is 1 nL, and the volume standard deviation is less than 11% when the loading volume is 5 nL. The droplets can be by centrifugation. Multi-step reactions and concentration gradient configurations can be achieved by multiple injections of reagents. The  system was used for PCR screening and single-cell phenotypic screening of pathogenic microbial single-cell resistance genes. It was also fused to a FACS system and used for single cell gene expression analysis of animal cells. 

CAS news release, October 10, 2019

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