Using a thioredoxin-fused TALE system, the groups around Tao XU and colleagues achieved high-quality imaging at various genomic loci and observed aging-associated (epi) genomic alterations at telomeres and centromeres in human and mouse premature aging models. They identified attrition of ribosomal DNA repeats as a molecular marker for human aging which may be used as a simple and robist imaging marker method.
CAS news release, April 4, 2017