Using a mouse strain suffering from cataracts, the group around Jinsong LI at SIBS Institute of Biochemistry and Cell Biology isolated spermatogonial stem cells from these mice and treated them with CRISPR-Cas9 technologies. After transplantation of the treated cells in the testes of recipient mice, 100 % completely healthy mice were obtained, suggesting a new procedure for gene therapy.
CAS news release, Dec. 9, 2014